1. Basic Principle of VHP Vaporized Hydrogen Peroxide Sterilization VHP (Vaporized Hydrogen Peroxide) sterilization relies on the powerful oxidizing properties of gaseous hydrogen peroxide. Compared with liquid hydrogen peroxide, vaporized hydrogen peroxide exhibits far stronger bactericidal and sporicidal efficacy at room temperature. During operation, vaporized hydrogen peroxide releases free hydroxyl radicals, which penetrate microbial cell membranes and oxidatively destroy microbial lipids, proteins, and DNA structures. This process permanently inactivates bacteria, fungi, viruses, and bacterial spores, achieving a 6-log sterilization level that meets industrial standards. After sterilization, hydrogen peroxide completely decomposes into water and oxygen without residues or secondary contamination. As a low-temperature decontamination technology, it is widely applicable for sterilizing enclosed spaces and high-precision equipment in clean environments.

     2. FAQ for SUZHOU HJCLEAN TECH CO., LTD VHPS Series Sterilizers 

    Q1: What is the VHPS series hydrogen peroxide sterilizer? The VHPS series is a professional room-temperature biological decontamination and sterilization equipment independently developed by Suzhou HJCLEAN Tech. The device vaporizes 30%–35% high-purity hydrogen peroxide solution into hydrogen peroxide vapor through a dedicated vaporizer. The generated vapor is evenly delivered to enclosed spaces via customized pipelines to achieve comprehensive, dead-angle-free sterilization in full compliance with cleanroom and GMP specifications.

    Q2: What is the core working principle of the VHPS sterilizer? 

    The core principle takes full advantage of the fact that gaseous hydrogen peroxide possesses significantly higher sporicidal activity than liquid hydrogen peroxide at room temperature. The vapor generates abundant free hydroxyl radicals, which actively attack and destroy key cellular components of microorganisms, including lipids, structural proteins, and genetic DNA. This thorough inactivation mechanism eliminates common microorganisms and highly resistant bacterial spores, achieving reliable and complete sterilization with zero chemical residues under ambient temperature conditions. 

   Q3: What are the application scenarios of the VHPS sterilizer? 

   The VHPS sterilizer is suitable for room-temperature sterilization and biological decontamination of various enclosed clean spaces. Typical application scenarios include sterile transfer hatches, pharmaceutical filling machines, freeze dryers, sterile isolators, GMP-grade cleanrooms, biosafety laboratories, and closed sampling chambers, covering mainstream pharmaceutical, biotech and industrial clean production environments. 

   Q4: What is the difference between VHP vapor sterilization and conventional liquid hydrogen peroxide wiping disinfection? 

    Traditional wiping with 3% liquid hydrogen peroxide only provides surface-level disinfection, which cannot eliminate bacterial spores or penetrate gaps and hidden dead areas. In comparison, the VHPS series adopts high-concentration vaporization technology. The highly permeable hydrogen peroxide vapor penetrates equipment crevices, internal pipelines and chamber blind spots, delivering genuine sporicidal sterilization results that fully satisfy GMP validation requirements. 

    Q5: What are the requirements for consumables? 

    The equipment requires dedicated 30%–35% medical-grade hydrogen peroxide solution as standard consumables. Dilution or replacement with low-concentration hydrogen peroxide is prohibited. Substandard solution concentration will drastically reduce vapor sterilization activity, resulting in incomplete sterilization and failed GMP validation. 

     Q6: What is the standard operating procedure for VHPS sterilization?

     Pre-treatment: Remove surface oil stains and organic contaminants, fully seal the target space, adjust temperature and humidity to the optimal process range, evacuate all personnel and post safety warning signs. Environmental conditioning: The equipment automatically dehumidifies and stabilizes ambient conditions to prevent vapor condensation and liquefaction. Vaporization and sterilization: Hydrogen peroxide solution is quantitatively vaporized and transported into the enclosed space to maintain a stable concentration for sufficient sterilization exposure. Aeration and residual elimination: The system automatically ventilates and decomposes residual vapor until the hydrogen peroxide concentration drops to a safe level for human entry. Sterilization validation: Verify sterilization effectiveness via biological and chemical indicators, and archive all process data completely. 

    Q7: Will VHPS sterilization damage equipment or materials? 

    Operating under ambient temperature conditions, the VHPS sterilizer features excellent material compatibility. It is safe for stainless steel, glass, PP, PVC, standard silicone, and sophisticated electronic devices. Copper, brass and galvanized metal materials are susceptible to oxidative corrosion during long-term exposure; material compatibility testing is recommended before use for such equipment. 

    Q8: What are the safety precautions for VHPS operation? 

    All personnel must leave the sterilization area during operation with warning signs posted visibly. Wear safety goggles and chemical-resistant gloves when handling high-concentration hydrogen peroxide stock solution. Mixing hydrogen peroxide with alcohol or chlorine-based disinfectants is strictly prohibited. Always complete the full residual aeration cycle and confirm safe residual concentration before staff re-entry. 

    Q9: What factors may lead to unqualified sterilization results? 

    Sterilization failure is mainly caused by the following factors: poor space sealing leading to vapor leakage, residual organic contaminants consuming effective sterilizing components, temperature and humidity exceeding the qualified process range, substandard hydrogen peroxide concentration, blocked pipelines or uneven vapor diffusion, and overstacked materials causing unreachable sterilization blind zones. 

    Q10: What are the core advantages of the VHPS sterilizer? 

    It adopts room-temperature sterilization, making it suitable for heat-sensitive precision equipment; high-permeability vapor eliminates sterilization dead angles; the sterilization process produces only water and oxygen with zero residues and no secondary pollution; fully automatic operation with fully traceable process data complies with GMP and ISO quality standards; the all-in-one design adapts to multiple enclosed clean spaces with strong versatility. 

    Q11: How to maintain the equipment daily? 

    Daily maintenance includes regular inspection of sealing performance for door gaskets and delivery pipelines, periodic calibration of temperature, humidity and concentration sensors, routine cleaning of the vaporizer to prevent scaling, and timely replacement of expired or deteriorated hydrogen peroxide consumables to ensure stable and consistent equipment performance. 

    Q12: Is customized service available for non-standard scenarios? 

   Customized services are available for non-standard working conditions. We can provide tailored sterilization solutions including customized pipeline layout, adjustable dosing flow and personalized sterilization programs according to the actual volume, structural layout and process requirements of large cleanrooms, multi-unit isolators, large-scale freeze dryers and other special sites.